(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
ICI 118551 Hydrochloride
CAS: 72795-01-8
Molecular Formula: C17H28ClNO2
(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride - Names and Identifiers
(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride - Physico-chemical Properties
| Molecular Formula | C17H28ClNO2 |
| Molar Mass | 313.86272 |
| Appearance | powder |
| Color | white |
| Storage Condition | desiccated |
| In vitro study | ICI 118551 inhibits cAMP accumulation with IC 50 of 1.7 μM in IMCD cells. ICI 118551 (10 μM) induces a prominent vasorelaxation of norepinephrine (NE)-precontracted PA but not AO. In failing human heart, ICI 118551 has significant effects on beat duration, with time-to-peak contraction and time-to-90% relaxation reduced compared with basal contraction. Negative Inotropic Effect of ICI 118551 Is Not cAMP-Related. Overexpression of β2AR in rabbit myocytes enhances negative inotropic effects of ICI 118551. |
| In vivo study | ICI 118551 (0.2 mg/kg) injected into the jugular vein of the mice, reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure. |
(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride - Risk and Safety
| WGK Germany | 3 |
(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.186 ml | 15.931 ml | 31.861 ml |
| 5 mM | 0.637 ml | 3.186 ml | 6.372 ml |
| 10 mM | 0.319 ml | 1.593 ml | 3.186 ml |
| 5 mM | 0.064 ml | 0.319 ml | 0.637 ml |
Last Update：2024-01-02 23:10:35
(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride - Reference Information
| biological activity | ICI 118,551 hydrochloride is a highly selective β2 adrenergic receptor antagonist that binds to β2, the Ki values of β1 and β3 adrenergic receptors are 0.7,49.5 and 611 nM, respectively. |
| Target | Ki: 0.7nM (β2 receptor), 49.5 nM (β1 receptor), 611 nM (β3 receptor) |
Last Update：2024-04-09 21:54:55
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CAS: 72795-01-8
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Product Name: ICI 118551 Hydrochloride Visit Supplier Webpage Request for quotation
CAS: 72795-01-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 72795-01-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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